Which organ function should be monitored because of divalproex sodium's risk of hepatotoxicity?

Which organ function should be monitored because of divalproex sodium's risk of hepatotoxicity?

• A. Liver function
• B. Kidney function
• C. Thyroid function
• D. Pulmonary function

Answer: (A)

Valproate compounds carry a real risk of serious liver injury, so monitoring liver function is essential. Before starting therapy, baseline liver tests should be drawn, and then you should follow up regularly—especially during the first six months of treatment. Track enzymes such as AST and ALT, as well as bilirubin and alkaline phosphatase, since elevations can signal hepatotoxicity. Be alert for symptoms like fatigue, loss of appetite, nausea, vomiting, abdominal pain, or jaundice, which may indicate liver trouble. If liver tests rise significantly or symptoms appear, reevaluate the therapy promptly.

Valproate compounds carry a real risk of serious liver injury, so monitoring liver function is essential. Before starting therapy, baseline liver tests should be drawn, and then you should follow up regularly—especially during the first six months of treatment. Track enzymes such as AST and ALT, as well as bilirubin and alkaline phosphatase, since elevations can signal hepatotoxicity. Be alert for symptoms like fatigue, loss of appetite, nausea, vomiting, abdominal pain, or jaundice, which may indicate liver trouble. If liver tests rise significantly or symptoms appear, reevaluate the therapy promptly.